Table 1.
Participant characteristics
| Variable | Units | Descriptor | N |
|---|---|---|---|
| Demographics | |||
| Age | Years M (SD) | 61.97 (7.48) | 9722 |
| Sex | F (%F) | 5105 (52.51) | 9722 |
| Ethnicity | White British (%) | 9519 (98) | 9722 |
| VRFs | |||
| Smokera,m | Current:Ex:Never | 399:3322:5910 | 9631 |
| Pack years | Years M (SD) | 4.76 (11.11) | 9631 |
| Hypertensiona,m | Yes (Yes%) | 2002 (20.59) | 9722 |
| Pulse pressurea,m | mm Hg M (SD) | 57.03 (13.39) | 9346 |
| Diabetesa,m | Yes (Yes%) | 476 (5.90) | 9722 |
| Hypercholesterolaemiaa,m | Yes (Yes%) | 1069 (11.00) | 9722 |
| BMIa,m | Kg/m2 median (IQR) | 26.08 (5.36) | 9693 |
| WHRa,m | W:H M (SD) | 0.86 (0.08) | 9695 |
| Brain MRI | |||
| Total brain volume | mm3M (SD) | 1 166 776 (110 729.90) | 9722 |
| Grey matter volume | mm3M (SD) | 615 142.30 (55 039.46) | 9722 |
| WMH volume | mm3 median (IQR) | 2147.00 (3007.00) | 8861 |
| gFA | Std units M (SD) | 0 (1) | 8601 |
| gMD | Std units M (SD) | 0 (1) | 8514 |
Heart or cardiac problem includes self-report of angina. Brain MRI volumes are raw values (uncorrected for head size). Significant positive association between greater vascular risk and aage, and m/fgender (see Supplementary material online, Table S3).
BMI, body mass index; VRF, vascular risk factor; WHR, waist–hip ratio; WMH, white matter hyperintensity, gFA and gMD (latent factors of white matter fractional anisotropy and mean diffusivity).