Table 1.
Before matching |
Propensity-score matched |
|||||
---|---|---|---|---|---|---|
No OAC (n = 52 094) | OAC (n = 39 160) | Standardized differences | No OAC (n = 23 746) | OAC (n = 23 746) | Standardized differences | |
Age, mean | 57.1 | 61.4 | −0.411 | 60.8 | 61.5 | −0.079 |
Female sex | 35.1% | 29.1% | 0.129 | 29.9% | 30.7% | −0.017 |
CHA2DS2-VASc, mean | 0.83 | 0.95 | −0.174 | 0.88 | 0.91 | −0.042 |
>1 year since first AF diagnosis | 20.5% | 20.7% | −0.004 | 18.7% | 19.7% | −0.024 |
Myocardial infarction | 1.7% | 1.2% | 0.041 | 1.2% | 1.3% | −0.001 |
Peripheral artery disease | 0.6% | 0.9% | −0.027 | 0.4% | 0.5% | −0.014 |
Heart failure | 2.6% | 8.8% | −0.267 | 2.5% | 2.8% | −0.016 |
Any valvular disease | 3.7% | 10.6% | −0.269 | 3.7% | 4.4% | −0.035 |
Pacemaker/ICD | 3.2% | 4.7% | −0.076 | 2.8% | 3.2% | −0.023 |
Hypertension | 13.5% | 15.1% | −0.046 | 15.3% | 15.3% | 0.002 |
Diabetes | 2.0% | 2.3% | −0.016 | 1.7% | 1.9% | −0.016 |
Renal disease | 0.9% | 0.6% | 0.038 | 0.5% | 0.4% | 0.005 |
Liver disease | 1.8% | 0.8% | 0.090 | 0.5% | 0.6% | −0.006 |
Hospitalization for bleeding | 5.7% | 4.4% | 0.058 | 3.2% | 3.4% | −0.012 |
Venous thromboembolism | 1.7% | 4.7% | −0.174 | 2.0% | 2.1% | −0.010 |
Hypothyroidism | 2.8% | 2.4% | 0.020 | 1.9% | 2.1% | −0.010 |
Thyrotoxicosis | 1.5% | 1.8% | −0.023 | 1.2% | 1.4% | −0.019 |
Osteoarthritis | 10.5% | 12.4% | −0.059 | 12.1% | 12.6% | −0.016 |
Parkinson’s disease | 0.4% | 0.3% | 0.010 | 0.3% | 0.3% | −0.012 |
COPD | 3.3% | 3.0% | 0.013 | 2.0% | 2.4% | −0.028 |
Alcohol index | 6.0% | 2.6% | 0.169 | 2.2% | 2.5% | −0.018 |
Cancer ≤3 years | 7.0% | 4.0% | 0.131 | 4.2% | 4.4% | −0.007 |
Frequent falls | 1.3% | 0.9% | 0.044 | 0.6% | 0.7% | −0.013 |
Drugs used at baseline | ||||||
ACE inhibitor or ARB | 17.6% | 34.5% | −0.394 | 23.1% | 23.2% | −0.003 |
Diuretic | 11.3% | 22.5% | −0.303 | 12.4% | 13.1% | −0.020 |
Statin | 14.0% | 18.1% | −0.114 | 15.7% | 16.5% | −0.023 |
Nitrates | 5.0% | 4.6% | 0.006 | 4.1% | 4.4% | −0.016 |
Beta blocker | 59.8% | 82.5% | −0.516 | 78.2% | 78.6% | −0.010 |
Antiarrhythmic drug Class 1 or 3 | 5.5% | 6.3% | −0.035 | 5.6% | 6.7% | −0.047 |
Digoxin | 4.1% | 16.9% | −0.428 | 4.8% | 5.3% | −0.026 |