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. Author manuscript; available in PMC: 2019 Jul 21.
Published in final edited form as: Sci Signal. 2018 Feb 20;11(518):eaao0422. doi: 10.1126/scisignal.aao0422

Fig. 1. Abl and Arg mRNAs are increased in melanoma cell lines and primary melanomas.

Fig. 1.

(A) Abl/Arg kinase activities (kinase assay) and protein abundance were assessed in serum-starved melanoma cell lines or primary melanocytes (HEMn). mRNAs were quantitated with qPCR. Mean±SEM, n=2, normalized to RPS13. Western protein blots and kinase assays are part of Supplementary Materials for a recent manuscript (26). The data are reshown since they are critical for comparison to mRNA data. (B) Oncomine (Talantov dataset-left 2 panels) and TCGA data (right panel) were statistically reanalyzed using two-sample t-tests (for normally distributed data; Shapiro Wilk test) or Wilcoxon rank-sum tests. Nevi=benign nevi