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Usages of the TRBV and TRBJ genes of the TCRB repertoire in bDMARD-treated RA patients. The heatmaps illustrate fractions of (a) TRBV and (b) TRBJ genes of RA patients receiving different courses of bDMARD treatment in a color spectrum between white (low) and red (high). The intragroup repertoire dissimilarity index (RDI) values of (c) TRBV, (d) TRBJ, and (e) V-J combinations between each pair of RA patients are illustrated.
