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. Author manuscript; available in PMC: 2019 Nov 20.
Published in final edited form as: Nat Struct Mol Biol. 2019 May 20;26(6):397–406. doi: 10.1038/s41594-019-0220-3

Figure 2. TFIIE links human PIC to TFIIH.

Figure 2.

a, Sequence of the DNA substrate in PIC. b, Cartoon of human PIC structure including TFIIH highlighting non-TFIIH subunits. Most striking is TFIIE which crosses over a quarter of TFIIH. Model is based on integration and comparative analysis of cryo-EM densities for human apo-TFIIH, human closed-state holo-PIC density, and yeast core-PIC–TFIIH–DNA c, Computed B-factors mapped onto the PIC-TFIIH structural model with values colored from high (red) to low (blue) reveal a network of stable interactions. Black dashed outline highlights an unexpected rigid anchor region between TFIIH and PIC.