Body weight of A) male and B) female, WT, and Cyp2b-null mice were monitored during the 10-week feeding study. Male but not female Cyp2b-null mice show increased weight during HFD treatments. Data are represented as mean ± SEM. Statistical significance was determined by one-way ANOVA followed by Fisher’s LSD as the post-hoc test (n= 8-9). An ‘a’ indicates WT-ND are different than Cyp2b-null-ND, ‘b’ indicates WT-ND are different than WT-HFD, ‘c’ indicates Cyp2b-null-ND are different than Cyp2b-null-HFD, ‘d’ indicates WT-HFD are different than Cyp2b-null-HFD.