Table 2:

Serum lipid levels in Cyp2b9/10/13-null compared to WT mice treated with normal diet (ND) or high fat diet (HFD) in male (A) and female (B) mice.

A

Lipid panel	WT ND M	WT HFD M	Cyp2b-null ND M	Cyp2b-null HFD M
ALT	17.00 ± 1.48	15.00 ± 0.55	17.80 ± 0.97	14.00 ± 1.00
β-OHB	0.188 ± 0.015	0.162 ± 0.022	0.120 ± 0.015	0.365 ± 0.087^c*^d^
Cholesterol	103.80 ± 1.63	170.4 ± 7.00^b^**	118.60 ± 6.27^a^*	182.75 ± 3.61^c^**^d
Fatty acids	833.7 ± 97.3	740.2 ± 93.0	739.3 ± 36.6	751.4 ± 43.2
HDL	97.00 ± 2.21	150.76 ± 6.24^b^**	114.02 ± 4.45^a^*	168.60 ± 4.94^c^*^d^
LDL	10.98 ± 0.58	26.34 ± 2.46^b^*	16.34 ± 1.09	30.20 +/− 1.57^c
Triglycerides	80.40 ± 7.88	69.60 ± 3.96^b	58.00 ± 5.93^a^**	52.25 ± 3.15^d^*
VLDL	16.04 ± 1.59	13.94 ± 0.80	11.56 ± 1.19^a	10.45 ± 0.61
B

Lipid panel	WT ND F	WT HFD F	Cyp2b-null ND F	Cyp2b-null ND F
ALT	20.20 ± 1.69	37.20 ± 8.49	17.80 ± 0.80	17.80 ± 0.80
β-OHB	0.325 ± 0.076	0.360 ± 0.061	0.328 ± 0.098	0.268 ± 0.046
Cholesterol	76.40 ± 3.70	98.00 ± 12.63	77.40 ± 1.94	77.40 ± 1.94
Fatty acids	374.0 ± 8.19	380.4 ± 27.2	343.9 ± 20.5	366.5 ± 30.6
HDL	72.48 ± 4.09	54.18 ± 22.92	77.36 ± 2.57	77.36 ± 2.57
LDL	8.68 ± 1.82	8.58 ± 3.24	10.20 ± 1.46	10.20 ±1.46
Triglycerides	80.80 ± 17.74	78.40 ± 18.58	57.40 ± 12.70	57.40 ± 12.70
VLDL	16.16 ± 3.53	11.46 ± 2.52	15.68 ± 3.75	20.48 ± 3.55

Data represented as mean +/− SEM (n = 5). All units expressed as mg/dl except β-OHB (mM), fatty acids (μM) and ALT (U/L). Statistical significance was determined by one-way ANOVA followed by Fisher’s LSD as the post-hoc test.

^‘a’

indicates WT ND different than Cyp2b9/10/13-null ND.

^‘b’

indicates WT ND different than WT HFD

^‘c’

indicates Cyp2b9/10/13-null ND different than Cyp2b9/10/13-null HFD.

^‘d’

indicates WT HFD different than Cyp2b9/10/13-null HFD,

No asterisk indicates a p-value ≤ 0.05 and

indicates a p-value ≤ 0.01,

^**

indicates a p-value of ≤ 0.0001.