Table 3:
Comparison of the number of up- and down-regulated genes within specific KEGG pathways of male and female Cyp2b-null ND-fed mice.
| KEGG Pathway | Male Cyp2b-null ND vs WT ND | Female Cyp2b-null ND vs WT ND |
|---|---|---|
| PI3K-Akt signaling | 11 | 5 |
| Protein processing in endoplasmic reticulum | 10 | 4 |
| Retinol metabolism | 7 | 2 |
| MAPK signaling | 7 | 3 |
| Glycerophospholipid metabolism | 7 | 2 |
| Apoptosis | 6 | 4 |
| Drug metabolism | 6 | 1 |
| Thyroid hormone signaling | 6 | 1 |
| Insulin resistance/signaling | 5 | 4 |
| PUFA metabolism | 5 | 1 |
| Circadian rhythm | 4 | 3 |
| NAFLD | 4 | 1 |
| Calcium signaling | 3 | 1 |
| FoxO signaling | 2 | 3 |
| Cholesterol metabolism | 1 | 3 |
| Sphingolipid metabolism | 1 | 2 |
| Total Perturbations | 646 | 190 |