Table 4:
Comparison of the number of up- and down-regulated genes within specific KEGG pathways.
| KEGG Pathway | Cyp2b-null ND vs WT ND | WT HFD vs WT ND | Cyp2b-null HFD vs WT HFD |
|---|---|---|---|
| PI3K-Akt signaling | 11 | 12 | 2 |
| Protein processing in endoplasmic reticulum | 10 | 1 | 0 |
| Retinol metabolism | 7 | 13 | 1 |
| MAPK signaling | 7 | 12 | 1 |
| Glycerophospholipid metabolism | 7 | 1 | 1 |
| Hepatocellular carcinoma | 6 | 11 | 1 |
| Drug metabolism | 6 | 9 | 0 |
| Thyroid hormone signaling | 6 | 5 | 1 |
| Apoptosis | 6 | 1 | 0 |
| PUFA metabolism | 5 | 10 | 3 |
| Insulin signaling/resistance | 5 | 3 | 2 |
| Circadian rhythm | 4 | 2 | 3 |
| NAFLD | 4 | 2 | 0 |
| Phospholipase D signaling | 4 | 0 | 0 |
| Glutathione metabolism | 2 | 12 | 0 |
| Cholesterol metabolism | 1 | 4 | 2 |
| Total Perturbations | 646 | 620 | 75 |