TABLE I.

Electrophysiological properties of the reduced granule cell model

Electrophysiological Property	Original Model	Reduced Model	Biological Value	General Description of Calculation
RMP (mV)	−73.5	−73.5	−75 ± 2a	The somatic membrane voltage at rest was measured.
			−74.7 ± 0.9b
RIn (MΩ)	169	170	228 ± 14.2c	A series of step currents of different amplitudes were applied to the soma and the slope of the steady-state voltage change per current amplitude was calculated.
			122 ± 13b
τmembrane (ms)	24.5	24.9	31 ± 2a	The repolarization of the somatic membrane voltage following a depolarizing current was fitted to an exponential function.
			16 ± 1b
AP Threshold (mV)	−50.4	−50.4	−49 ± 0.8c	The minimum voltage at which an action potential can be elicited was determined.
			−40.8 ± 0.6b
Fast AHP (mV)	−6.34	−2.88	−11.7 ± 1.1a	The difference between the peak AHP amplitude and the resting membrane potential after the firing of an action potential was measured.
			−7.6 ± 0.6b
Spike Frequency Adaptation Ratio	0.087 or 0.34	0.52 or 0.55	0.092 or 0.3c	The property was calculated as the ratio between (1) the initial inter-spike interval (ISI) and the final ISI or (2) the mean of the first two and last two ISIs.
Sag Ratio	1	1	0.97 ± 0.01a	The ratio was determined using the steady-state membrane voltage change following a hyperpolarizing current and the maximum change.
			1.0 ± 0.2b

Values report mean and standard deviation where applicable.

References:

^aLübke et al., 1998 [27];

^bKowalski et al., 2016 [28];

^cStaley et al., 1992 [29].