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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Neurosci Biobehav Rev. 2019 Apr 24;102:195–207. doi: 10.1016/j.neubiorev.2019.04.015

Figure 2: U2-Type Spliceosome Facilitated pre-mRNA Splicing Mechanism.

Figure 2:

Small nuclear ribonuceoprotein (snRNP) U2 facilitated spliceosome assembly begins with the U1 snRNP associating with the 5’ splice site and U2 at the branch point (complex A). The pre-assembled U4/U5/U6 tri-snRNP is recruited to form the pre-catalytic spliceosome (complex B1). U1 and U4 snRNPs are then destabilized by various protein interactions resulting in the catalytically active spliceosome (complex B2). The U2/U5/U6 spliceosome complex then facilitates intron excision and exon ligation via two step catalytic process (complex C).