Table 2B.
AT2 receptor expression in CRC tissues (n=161) according to pathological variables
| Variables | Weak (%) | Strong (%) | Total (n) | P value |
|---|---|---|---|---|
| Histologic Subtype | ||||
| AdC | 28.3 | 71.7 | 145 | 0.2 |
| MuC | 43.8 | 56.2 | 16 | |
| Histologic Grade | ||||
| G1 | 50 | 50 | 6 | 0.1 |
| G2 | 26.5 | 73.5 | 136 | |
| G3 | 47.4 | 52.6 | 19 | |
| Local Invasion (pT) | ||||
| pT2 | 26.2 | 73.8 | 42 | 0.002(a) |
| pT3 | 25.7 | 74.3 | 105 | |
| pT4 | 71.4 | 28.6 | 14 | |
| Affected Lymph Nodes (N) | ||||
| N0 | 26.3 | 73.7 | 95 | 0.1(b) |
| N1 | 29.4 | 70.6 | 51 | |
| N2 | 53.3 | 46.7 | 15 | |
| Stage (TNM system) | ||||
| I | 26.5 | 73.5 | 34 | 0.16(c) |
| II | 25 | 75 | 60 | |
| III | 33.3 | 66.7 | 63 | |
| IV | 75 | 25 | 4 | |
| Vascular Invasion (V) | ||||
| No | 27 | 73 | 141 | 0.035 |
| Yes | 50 | 50 | 20 | |
| Lymphatic Invasion (L) | ||||
| No | 27.1 | 72.9 | 133 | 0.097 |
| Yes | 42.9 | 57.1 | 28 | |
| Perineural Invasion (Pn) | ||||
| No | 28.1 | 71.9 | 139 | 0.22 |
| Yes | 40.9 | 59.1 | 22 | |
(a) AT2 expression was higher in pT2 (p=0.002) and pT3 (p=0.001) than in pT4 CRCs.
(b) Differences were found between N0 and N2 CRCs (p=0.03).
(c) Stage IV CRCs showed lower AT1 staining than Stage I (p=0.04) and II (p=0.03) ones.