Table 2.
Demography and baseline characteristics: Per protocol population
| Parameters | Placebo (n=29) | NXT15906F6-250 (n=30) | NXT15906F6-400 (n=30) | p-value |
|---|---|---|---|---|
| Age (years) | 45.3 ± 8.5 | 43.7 ± 6.7 | 45.1 ± 7.9 | 0.4134# 0.9095* |
| Male, n (%) | 14 (48.3) | 15 (50.0) | 15 (50.0) | - |
| Female, n (%) | 15 (51.7) | 15 (50.0) | 15 (50.0) | - |
| Weight (kg) | 63.4 ± 8.2 | 62.4 ± 6.4 | 63.1 ± 8.9 | 0.5943# 0.8942* |
| Height (m) | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.1 | 0.6842# 0.5023* |
| BMI (kg/m2) | 24.0 ± 2.5 | 23.4 ± 2.1 | 23.4 ± 2.4 | 0.3345# 0.3689* |
| SMWD (m) | 391.41±37.71 | 397.13±68.06 | 401.77±51.64 | 0.6903# 0.3820* |
| Average Speed (m/s) | 1.09±0.10 | 1.10±0.19 | 1.12±0.14 | 0.6903# 0.3820* |
| Stair climb test (s) | 11.01±2.1 | 11.33±2.36 | 11.14±1.91 | 0.5919# 0.8149* |
| Visual analogue scale (VAS) | 13.33±4.14 | 13.07±3.22 | 13.40±2.77 | 0.7943# 0.9314* |
| WOMAC-A (pain) | 55.86±19.41 | 56.83±15.17 | 55.67±13.50 | 0.8316# 0.9644* |
| WOMAC-B (Stiffness) | 23.79±7.87 | 23.50±9.02 | 22.67±7.85 | 0.8945# 0.5841* |
| WOMAC-C (Physical function) | 193.28±66.86 | 190.67±48.04 | 191.33±33.40 | 0.8644# 0.8890* |
| Total WOMAC | 272.93±86.6 | 271.00±62.21 | 269.67±42.79 | 0.9222# 0.8560* |
| Primary knee flexion (degrees) | 122.21±4.7 | 121.97±5.59 | 122.13±7.00 | 0.8587# 0.9623* |
Data presented as n (%) or mean ± SD. # intergroup analysis placebo vs. NXT15906F6-250; * placebo vs. NXT15906F6-400 using t-test, unequal variance