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Metformin downregulates HIF-1α expression at a posttranscriptional level. A. Metformin inhibited HIF-1α expression in a time- and dose-dependent manner, Columns represent the mean of at least three independent experiments; error bars represent the SD of the mean. *p<0.05. B. Metformin did not influence the mRNA levels of HIF-1α (NC. Not significant, p>0.05). C. Immunofluorescent staining showed that metformin inhibited HIF-1α expression.
