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PKM2 is involved in hypoxia-induced EMT. A. Hypoxia induced the expression of vimentin and decreased the levels of E-cadherin while silencing of PKM2 reversed this effect, the results were confirmed by densitometric quantified analysis (B), Columns represent the mean of at least three independent experiments; error bars represent the SD of the mean. *p<0.05. C. Knockdown of PKM2 impaired hypoxia-induced EMT (NC. Not significant, *p<0.05).
