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Metformin reverses EMT by inhibiting the HIF-1α/ PKM2 pathway. A. Metformin rescued the accumulation of vimentin and decreased the levels of E-cadherin in hypoxia-treated KFs. Metformin also inhibited phosphorylation of p70s6k and upregulated the expression of PKM2 in KFs under hypoxia condition; B. Columns represent the mean of at least three independent experiments; error bars represent the SD of the mean. *p<0.05.
