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. 2019 Jun 2;15(7):1472–1487. doi: 10.7150/ijbs.33817

Figure 6.

Figure 6

Prophylactic use of hypericin enhances the anti-oxidative ability of the pancreas and blocks islet β-cell apoptosis in HFHS-fed mice. (A-D) Assessment of anti-oxidative function in the mouse pancreas. Portions of the mouse pancreases from Fig. 5A were homogenized, and the homogenate supernatant was collected to measure T-AOC (A), SOD (B) and GSH-PX activity (C), and MDA content (D). Data are presented as the mean ± S.D. (n=6). *p<0.05, ***p<0.001 versus the HFHS group. (E) IHC staining of the mouse pancreas with the anti-CC3 antibody. Portions of the mouse pancreases from Fig. 5A were fixed and subjected to IHC analysis. The scale bar represents 50 μm. Islets are circled with dashed lines. Cells positive for CC3 are indicated by arrowheads.