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. 2019 May 20;15(7):1358–1367. doi: 10.7150/ijbs.27360

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HP downregulates the expression of stem-related genes and reduces ALDH1⁺ subpopulation in TNBC cells. (A-B) qRT-PCR showed that HP treatment downregulated the expression of stem-related genes Nanog, Oct4, and Bmi1 in Mb436 and SUM159 cells, compared to control (0 μg/mL). (C) Representative images showed that HP treatment (48 h) reduced ALDH1⁺ subpopulations in Mb436 and SUM159 cells. (D) Statistical histogram of HP reducing ALDH1⁺ subpopulationin Mb436 and SUM159 cells, compared to the control (0 μg/mL). Data are presented as means ± SD (n= 3). *, P<0.05 and **, P<0.01.