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. 2019 May 20;15(7):1358–1367. doi: 10.7150/ijbs.27360

Figure 5.

Figure 5

ERα-36 knockdown overwhelms the inhibitory effect of HP on xenograft tumors of TNBC cells. (A) Images of xenograft tumors showed that HP treatment significantly decreased the size of tumors in Mb436 Mock cell-derived tumor group, compared to control. Compared with Mb436 Mock cell-derived tumor group, the sizes of Mb436/sh36 cell-derived tumors were markedly reduced and HP treatment could not further reduce the sizes of tumors. (B) Statistics of tumor sizes in different groups. (C) IHC images showed that HP treatment significantly decreased the expression of ERα-36 in Mb436 Mock cell-derived tumor group, compared to control. (D) Statistics of IHC scores for ERα-36 in different groups. (E) IHC images showed that compared to control, HP treatment significantly decreased the expression of ALDH1 in Mb436 Mock cell-derived tumor group, but not in Mb436/sh36 cell-derived tumor group. (F) Statistics of IHC scores for ALDH1 in different groups. Data are presented as means ± SD (n= 3). (**, p <0.01 and NS, no significance).