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. 2019 Jun 4;15(8):1676–1684. doi: 10.7150/ijbs.35265

Figure 5.

Figure 5

Activation of the JNK and p38 MAPK pathways mediated by ROS accumulation. (A-B) HCT116 cells were pretreated with NAC (5 mM) for 2 h before exposure to oxaliplatin and ALT combination. The protein levels of p-p38, p38, p-JNK and JNK were determined by western blot. (C-D) RKO cells were pretreated with NAC (5 mM) for 2 h before exposure to oxaliplatin and ALT combination. The protein levels of p-p38, p38, p-JNK and JNK were determined by western blot. Data represent similar results from three independent experiments (* p< 0.05, ** p < 0.01).