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Combination of oxaliplatin and ALT showed synergistic antitumor activity on HCT116 tumor xenograft in nude mice. (A-B) Oxaliplatin and ALT combined treatment significantly decreased tumor volume and tumor weight (C) of HCT116 human colon cancer xenograft in nude mice. (D-F) The protein levels of p-p38, p38, p-JNK and JNK were determined by western blot. (G) The level of Ki-67 in tumor tissues was analyzed by immunohistochemical analysis.
