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. 2019 Jun 10;15(8):1733–1742. doi: 10.7150/ijbs.35138

Figure 2.

Figure 2

JQ-1 inhibits KLF5 expression in a dose- and time-dependent manner. A. HCC1806 and HCC1937 cells were treated with JQ-1 for 24 h. The protein level was detected by immunoblotting. c-MYC was used as a positive control. FGFBP and p21 are KLF5 target genes. B. The KLF5 protein levels were gradually decreased after HCC1806 and HCC1937 cells were exposed to JQ-1 for indicated time. GAPDH was used as a loading control. C. JQ-1 decreased the KLF5 mRNA levels in HCC1806 and HCC1937 cells. The mRNA levels of KLF5 were examined by qPCR. The error bars represent the SD of experimental triplicates. *, P<0.05, **, P<0.01, ***, P<0.001, t-test.