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. 2019 Jun 10;15(8):1733–1742. doi: 10.7150/ijbs.35138

Figure 4.

Figure 4

Compound 870 shows more potent activity than JQ-1 in terms of its ability to induce G1 cell cycle arrest and inhibit DNA synthesis. A.HCC1806 and HCC1937 cells were treated with the indicated JQ-1 and compound 870 for 24 h. The number of cells in each phase of the cell cycle was analyzed by flow cytometry. B. Quantification of panel A. The error bars represent the SD of experimental triplicates. C. JQ-1 and compound 870 inhibited DNA synthesis as evaluated by an Edu incorporation assay. HCC1806 and HCC1937 cells were treated with JQ-1 or compound 870 for 24 h. The value of bar is 100 μm. D. Quantification of panel C. The error bars represent the SD of experimental triplicates. **, P<0.01, ***, P<0.001, t-test.