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. 2019 Jun 10;15(8):1733–1742. doi: 10.7150/ijbs.35138

Figure 5.

Figure 5

THZ1 inhibits KLF5 expression and BLBC growth. A. HCC1806 and HCC1937 cells were treated with THZ1 for 24 h. The KLF5, FGFBP and c-MYC protein levels were detected by immunoblotting. THZ1 is a CDK7 inhibitor. B. THZ1 inhibited the KLF5 mRNA levels in HCC1806 and HCC1937 cells. The mRNA level of KLF5 was examined by qPCR after the cells were treated with 100 nM and 200 nM THZ1 for 12 h. The error bars represent the SD of experimental triplicates. *, P<0.05, **, P<0.01, ***, P<0.001, t-test. C. THZ1 inhibited HCC1806 and HCC1937 cell growth, as measured by the SRB assay. The cells were treated with THZ1 for 72 h.