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. Author manuscript; available in PMC: 2019 Jul 22.
Published in final edited form as: Lab Invest. 2010 Jun 7;90(10):1457–1467. doi: 10.1038/labinvest.2010.107

Figure 3.

Figure 3

Circadian expression profile of genes involved in the regulation of hepatic bile acid synthesis. Gene expression levels (relative to 18S expression) were measured at four time points (0700, 1300, 1900 and 0100 hours) in 6–7 female wild-type controls (open circles) or female intestine-selective FXR knockout mice (closed circles). Data are represented as mean ± s.d. Cyp7A1 and Cyp8B1 are key enzymes in bile acid synthesis, Shp is the second messenger of FXR and Dbp, Rev-erbα and E4bp4 are involved in maintaining the circadian rhythm of Cyp7A1 expression. ‘#’ Represents a significant difference with P<0.05 between the two analyzed strains.