Table 1.
Patient Characteristics
| Variable | Frequency (%) |
|---|---|
| Age median [range], years | 57.6 [28.6–84.0] |
| Gender | |
| Male | 39 (77%) |
| Female | 12 (23%) |
| Significant history of tobacco use | |
| Yes | 34 (67%) |
| No | 17 (33%) |
| Significant history of alcohol use | |
| Yes | 13 (25%) |
| No | 38 (75%) |
| Primary Site | |
| Oropharynx | 22 (43%) |
| Unknown Primary | 7 (13%) |
| Hypopharynx | 4 (8%) |
| Skin | 4 (8%) |
| Larynx | 4 (8%) |
| Major Salivary Gland | 4 (8%) |
| Sinonasal | 3 (6%) |
| Nasopharynx | 2 (4%) |
| Oral cavity | 1 (2%) |
| Pathology | |
| Squamous cell carcinoma | 47 (92%) |
| Acinic cell carcinoma | 1 (2%) |
| Adenoid cystic carcinoma | 1 (2%) |
| Myoepithelial carcinoma | 1 (2%) |
| Salivary duct carcinoma | 1 (2%) |
| T stage | |
| 2 | 2 (4%) |
| 3 | 7 (14%) |
| 4A | 36 (70%) |
| 4B | 4 (8%) |
| 4C | 2 (4%) |
| Prior neck dissection | |
| Yes | 27 (53%) |
| No | 24 (47%) |
| Chemotherapy (initial treatment) | |
| Yes | 36 (71%) |
| No | 15 (29%) |
| Median initial XRT dose [range], Gy | 66.0 [50–72] |
| Type of salvage Neck Dissection | |
| Modified Radical Neck Dissection | 36 (71%) |
| Radical Neck Dissection | 15 (29%) |
| Interstitial Brachytherapy | |
| Median dose [range], Gy | 60 [40–62] |
| Average dose ± std., Gy | 57.7 ± 4.8 |
| Average duration [range], d | 5 [3–6] |
| Average dose rate [range], cGy/h | 60 (36–90) |
XRT, radiation therapy; Gy, Gray; mo, months;
std., standard deviation; d, days; cGy/h, centiGray per hour;† mean time to neck recurrence is calculated for 14 patients who had local regional recurrence