Table 2.
Baseline characteristics of the study patients grouped by plasma D-dimer quartile
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Pvaluea | |
|---|---|---|---|---|---|
| (≤ 0.24) n = 226 | (0.25–0.56) n = 213 | (0.57–1.78) n = 219 | (>1.78) n = 219 | ||
| Age (years), median (IQR) | 59 (50–66) | 66 (58–74) | 66 (53–76) | 66 (57–76) | 0.000 |
| Sex (male), n (%) | 172 (76.1) | 152 (71.4) | 142 (64.8) | 135 (61.6) | 0.005 |
| BMI (kg/m2),(Mean ± SD) | 24.89 ± 3.52 | 24.79 ± 3.56 | 24.99 ± 3.64 | 25.69 ± 3.78 | 0.040 |
| Smoker, n (%) | 102 (45.1) | 90 (42.3) | 74 (33.8) | 71 (32.4) | 0.012 |
| Alcohol drinker, n (%) | 56 (24.8) | 51 (23.9) | 44 (20.1) | 41 (18.7) | 0.344 |
| Hypertension, n (%) | 138 (61.1) | 131 (63.5) | 130 (59.4) | 133 (60.7) | 0.972 |
| Diabetes mellitus, n (%) | 83 (36.7) | 71 (33.3) | 55 (25.1) | 72 (32.9) | 0.062 |
| CAD, n (%) | 18 (8.0) | 24 (11.3) | 27 (12.3) | 37 (16.9) | 0.036 |
| Atrial fibrillation, n (%) | 10 (4.4) | 23 (10.8) | 30 (13.7) | 47 (21.5) | 0.000 |
| Dyslipidemia, n (%) | 90 (39.8) | 80 (37.6) | 63 (28.8) | 76 (34.7) | 0.085 |
| Previous stroke, n (%) | 22 (9.7) | 38 (17.8) | 28 (12.8) | 28 (12.8) | 0.093 |
| NIHSS on admission, median (IQR) | 4 (3–7) | 5 (3–7) | 6 (3–7) | 7 (5–10) | 0.000 |
| SBP (mmHg), median (IQR) | 148 (134–165) | 145 (131–162) | 144 (130–162) | 152 (134–166) | 0.221 |
| DBP (mmHg), median (IQR) | 85 (78–95) | 82 (76–90) | 80 (74–90) | 84 (76–93) | 0.001 |
| FBG (mmol/L), median (IQR) | 5.7 (4.66–8.23) | 6.01 (4.95–7.85) | 5.90 (4.78–7.46) | 6.23 (5.00–9.10) | 0.089 |
| D-dimer (mg /L), median (IQR) | 0.17 (0.12–0.21) | 0.38 (0.31–0.48) | 0.92 (0.72–1.27) | 3.06 (2.45–3.97) | 0.000 |
| Stroke etiology, n (%) | 0.000 | ||||
| Large-vessel occlusive | 81 (35.8) | 82 (38.5) | 86 (39.3) | 95 (43.4) | |
| Small-vessel occlusive | 118 (52.2) | 93 (43.7) | 91 (41.6) | 64 (29.2) | |
| Cardioembolic | 7 (3.1) | 18 (8.5) | 24 (11) | 39 (19.8) | |
| Other | 12 (5.3) | 7 (3.3) | 5 (2.3) | 6 (2.7) | |
| Unknown | 8 (3.5) | 13 (6.1) | 13 (5.9) | 15 (6.8) | |
| Mortality, n (%) | 4 (1.8) | 13 (6.1) | 24 (11) | 36 (16.4) | 0.000 |
BMI body mass index, CAD coronary artery disease, NIHSS National Institutes of Health Stroke Scale, SBP systolic blood pressure, DBP diastolic blood pressure, IQR interquartile range, SD standard deviation
a P value was assessed χ2 test, ANOVA or Mann–Whitney U tests, as appropriate