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Examples of potentially druggable cavities that are aligned together to demonstrate the conformational conservation in (a) 2AAA and (b) c-Myc. In each panel, a potentially druggable cavity was chosen as the reference conformation to align other cavities based on common atoms. Common atoms are shown in sticks and surfaces, whereas other parts are shown as lines. Insets are magnified sections. Graphics is prepared using PyMOL.
