Table 1. Properties of the Examined IDPs in pE-DB.

	pE-DB id	name	method	conf. number	druggable cavity number	average atom number of druggable cavity	pcommon	rmsd (Å)
single chain	1AAA	phosphorylated Sic1	SAXS & NMR	32	8	227.1	0.40 ± 0.19	6.59 ± 1.63
	1AAD	β-synuclein	NMR	575	431	263.1	0.43 ± 0.20	7.83 ± 3.08
	2AAA	unbound p27KID domain	MD	130	6	204	0.67 ± 0.12	5.14 ± 0.92
	2AAD	α/β-synuclein hybrid	NMR	576	511	281.2	0.38 ± 0.18	8.14 ± 2.73
	4AAB	Sendai nucleocapsid protein	NMR	13 718	1300	214.8	0.62 ± 0.16	7.08 ± 1.79
	5AAA	ParE2-associated antitoxin (PaaA2)	SAXS & NMR	50	20	272.1	0.61 ± 0.15	7.23 ± 1.78
	6AAA	p15PAF	SAXS & NMR	4939	1967	247.8	0.52 ± 0.19	7.76 ± 2.24
	6AAC	K18 domain of Tau protein	NMR	995	9	280.1	0.49 ± 0.20	8.71 ± 3.38
	7AAC	N-TAIL measles nucleoprotein	NMR	995	46	295.0	0.62 ± 0.17	10.26 ± 2.90
	8AAC	protein enhancer of sevenless 2B	SAXS & NMR	1700	64	192.8	0.55 ± 0.15	6.97 ± 1.68
	9AAC	α-synuclein	NMR	576	400	255.4	0.42 ± 0.18	7.83 ± 2.53
	n.a.	c-Myc370–409	MD	16 716	47	152.7	0.53 ± 0.17	5.49 ± 1.68
multichain	2AAB	heat shock protein β-6 (HSPB6) fragment (24–160)	SAXS	8	7	290.9	0.25 ± 0.16	8.44 ± 1.52
	3AAA	CYNEX4 flexible multidomain FRET probe	SAXS	17	11	572.5	0.32 ± 0.17	8.04 ± 4.54
	3AAB	heat shock protein β-6 (HSPB6) fragment (40–160)	SAXS	4	15	492.4	0.79 ± 0.23	2.66 ± 2.88
	4AAA	CYNEX4 T266 mutant flexible multidomain FRET probe	SAXS	16	13	519.9	0.26 ± 0.14	5.01 ± 4.32
	5AAC	phosphorylated Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase	SAXS & NMR	44	71	390.2	0.50 ± 0.19	3.65 ± 2.46
	7AAA	heat shock protein β-6 (HSPB6)	SAXS	6	18	359.4	0.25 ± 0.16	6.60 ± 2.43
	8AAA	heat shock protein β-6 (HSPB6) fragment (57–160)	SAXS	3	8	675	0.58 ± 0.16	1.75 ± 0.62