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. 2019 Jun 24;9(16):4608–4623. doi: 10.7150/thno.35188

Figure 1.

Figure 1

AQB has low IC50 in cancer cells expressing high levels of HOTAIR and EZH2. A) The docking results of AQB, HOTAIR, and EZH2. One nitrobenzene fragment of AQB formed π-π stacking with the 5'functional domain of HOTAIR. B) Box plot of 8 high-expressing HOTAIR and EZH2 tumors from TCGA Pan-Cancer Atlas Hub. C) Cell viability assay for glioblastoma and breast cancer cell lines after treatment with AQB for 2 days. Bars represent 3 independent experiments. D) The correlation analysis between the IC50 and levels of HOTAIR (left) or EZH2 (right) in 18 cell lines.