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. 2019 Jun 24;9(16):4608–4623. doi: 10.7150/thno.35188

Figure 5.

Figure 5

AQB (50mg/kg) inhibits tumor growth and metastasis in MDA-MB-231 orthotopic breast cancer model. A) Bioluminescence images from 3 representative DMSO-treated and AQB-treated mice on days 0, 20, and 40 of drug treatment. B) Quantitation of bioluminescence values for DMSO- and AQB-treated mice. C) Tumor volume was measured every 4 days after drug treatment. D) DMSO- and AQB-treated tumors were collected. E) The wet weight of DMSO-treated tumors and AQB-treated tumors. F) Bioluminescence images of the heart, liver, spleen, lung, and kidney. G) Representative lungs from DMSO- and AQB-treated mice. Arrows indicate the metastatic foci (left). Corresponding H&E staining and amplifying images (right). H) Representative confocal images display levels of APC2, β-catenin, HOXD10, PCDH10, Ki-67, and Vimentin in tumor sections. Nuclei were stained by DAPI. Scale bar, 40 µm. In B), C) and E), the data are presented as the mean±s.d.; n=5 mice. ****P<0.00001, ***P<0.0001, **P<0.001, two-tailed unpaired Student's t-test.