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. 2019 Jun 24;9(16):4608–4623. doi: 10.7150/thno.35188

Figure 7.

Figure 7

Antitumor activity of AQB and/or DZNep in orthotopic breast cancer model. A) Representative bioluminescence images of MDA-MB-231 orthotopic breast cancer mice that were treated with DMSO, AQB (0.2mg/kg), DZNep (1mg/kg), and the combination of AQB (0.2mg/kg) and DZNep (0.2mg/kg) at days 15 and 30. Day 0 was the time point prior to drug treatment. B) Quantitation of bioluminescence values. Data are presented as mean ± s.d.; n = 5 mice. ****P<0.00001, ***P<0.001, **P<0.001, *P<0.05. C) Tumor volume was measured every 2 days after drug treatment. Data are presented as mean ± s.d.; n = 5 mice. ****P<0.00001, **P<0.001, *P<0.05. D) Tumor size. E) Bioluminescence images of the heart, liver, spleen, lung, and kidney. Interrelated H&E staining shows the lung metastasis (bottom panel). The black arrows indicate tumors. F) Representative confocal images display levels of APC2, β-catenin, Ki-67, and Vimentin in the tumor sections. The nuclei were stained by DAPI. Scale bar, 40 µm.