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The ESCMe showed therapeutic effect on apoptosis, proliferation and intratumoral microvascular structures in tumor-bearing mice. exerts powerful anti-tumor activity (A) Staining of PCNA in tumors and surrounding skin tissues obtained from mice 21 days after treatment with PBS, ESCs, or ESC-CM. (B,C) TUNEL (B) and PAS-CD34 double staining (C) in tumor tissues. Red arrowheads mark VM; black arrowheads mark normal endothelial-dependent vessels. Scale bar, 50 μm. (A-C)
