Table 3.
Univariate and multivariate analyses of predictors of OS in 268 GIST patients
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | P-value | HR | 95%CI | P-value | |
| Age (≤58, >58) | 1.409 | 0.698–2.536 | 0.312 | 1.465 | 0.681–2.735 | 0.310 |
| Gender (male, female) | 0.963 | 0.476–1.998 | 0.039* | 1.201 | 0.458–2.340 | 0.112 |
| Tumor site (stomach, other) | 1.740 | 1.087–2.715 | 0.035* | 3.309 | 1.901–5.213 | 0.271 |
| Tumor size (≤10cm, >10cm) | 3.297 | 2.298–4.830 | 0.001** | 3.167 | 1.428–5.116 | ＜0.001** |
| Mitosis count (≤5/50 HPFs, >5/50 HPFs) | 3.615 | 2.866–5.981 | 0.000** | 4.527 | 2.270–7.158 | ＜0.001** |
| Tumor rupture (no, yes) | 3.226 | 2.259–5.672 | 0.038* | 8.210 | 4.614–13.992 | 0.048* |
| PENK (positive, negative) | 1.460 | 1.300–1.897 | 0.000** | 1.596 | 1.006–2.914 | ＜0.001** |
Notes: *P<0.05; **P<0.01. 95%CI, 95% confidence interval.
Abbreviations: GIST, gastrointestinal stromal tumor; HPF, high-power field; HR, hazard ratio; OS, overall survival; PENK, proenkephalin.