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. 2019 Apr 29;9(7):2061–2070. doi: 10.1534/g3.119.400193

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Copyright © 2019 Pletcher et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Disruption of GPI-anchor biosynthesis induces a rough eye phenotype. (A) A diagram illustrating GPI-anchor biosynthesis. Diagram is based upon KEGG pathway dme00563. Abbreviations: Phosphatidyl-1D-myo-inositol (PtdIns); Dolichyl phosphate D-mannose (DPM). (B-D) Representative images showing the rough eye phenotype caused by RNAi-induced disruption of (B) PIG-H, targeted using BDSC 67330, (C) PIG-M, targeted using BDSC 38321, and (D) PIG-O, targeted using BDSC 67247. For all images, eya composite-GAL4 is abbreviated eya comp.