Table 3. Selective pattern analyzed by Branch-site model.

Genes	Branch-site modelsa	-lnLb	2ΔlnL	p-value	ω values	Positively selected sitec
GSTA1	Teminal branch of Lwe
	ma	4319.495			ω0 = 0.092 ω1 = 1.0 ω2 = 338.762	45-0.962*, 48-0.875, 52-0.875, 59-0.800, 64-0.853, 70-0.848, 184-0.864, 185-0.998**, 186-0.895, 201-0.827
	ma0	4343.658	48.325	<0.001	ω0 = 0.079 ω1 = 1.0 ω2 = 1.0
GSTA4	Teminal branch of Hsa
	ma	2757.115			ω0 = 0.102 ω1 = 1.0 ω2 = 999	42-0.947, 185-0.961*
	ma0	2762.892	11.555	<0.001	ω0 = 0.096 ω1 = 1.0 ω2 = 1.0
GSTM1	Teminal branch of Odi
	ma	3851.226			ω0 = 0.104 ω1 = 1.0 ω2 = 24.372	35 D 0.996**, 44 W 0.870, 82 H 0.869, 94 R 0.860, 166 R 0.873, 215 N 0.989*,
	ma0	3855.022	7.592	0.006	ω0 = 0.104 ω1 = 1.0 ω2 = 1.0
	LCA of Lwe and Odi
	ma	3856.774			ω0 = 0.113 ω1 = 1.0 ω2 = 88.802	93 I 0.943
	ma0	3860.499	7.450	0.006	ω0 = 0.111 ω1 = 1.0 ω2 = 1.0
GSTT1	Teminal branch of Laf
	ma	3407.906			ω0 = 0.12 ω1 = 1.0 ω2 = 999.0	172-0.943, 219-0.939,
	ma0	3411.690	7.565	0.006	ω0 = 0.119 ω1 = 1.0 ω2 = 1.0
	Teminal branch of Mlu
	ma	3408.749			ω0 = 0.126 ω1 = 1.0 ω2 = 999	218-0.925,
	ma0	3412.490	7.483	0.006	ω0 = 0.12 ω1 = 1.0 ω2 =1.0
GSTT2	Teminal branch of Bta
	Ma	3764.990			ω0 = 0.104 ω1 = 1.0, ω2 = 999	237-0.876, 239-0.987*
	Ma0	3780.489	30.999	<0.001	ω0 = 0.106, ω1 = 1.0, ω2 = 1
	Teminal branch of Eca
	Ma	3765.226			ω0 = 0.102 ω1 = 1.0, ω2 = 999	18- 0.977*, 19- 0.971*, 21-0.964*, 24-0.895, 26-0.926, 30-0.936, 143-0.941
	Ma0	3775.418	20.384	<0.001	ω0 = 0.098 ω1 = 1.0, ω2 = 1
	Teminal branch of Tla
	ma	3770.135			ω0 = 0.096 ω1 = 1.0 ω2 = 999	13-0.936, 28-0.953*, 89-0.922, 93-0.986*, 190-0.866
	ma0	3776.142	12.014	<0.001	ω0 = 0.091 ω1 = 1.0 ω2 = 1.0
GSTP2	Teminal branch of Oar
	ma	2704.119			ω0 = 0.069 ω1 = 1.0 ω2 = 999	113-0.989*, 114-0.961*, 205-0.804, 210-0.951*
	ma0	2717.934	27.631	<0.001	ω0 = 0.063 ω1 = 1.0 ω2 = 1.0
	LCA of Lwe and Odi
	ma	2711.299			ω0 = 0.059 ω1 = 1.0 ω2 = 10.047	106-0.890, 135-0.953*, 144-0.869, 174-0.987*, 208-0.878,
	ma0	2714.800	7.002	0.008	ω0 = 0.059 ω1 = 1.0 ω2 = 1.0
	Teminal branch of Pho
	ma	2707.268			ω0 = 0.056 ω1 = 1.0 ω2 = 15.788	3-0.814, 4-0.997**, 6-0.995**, 7-0.952*, 8-0.808
	ma0	2711.251	7.965	0.005	ω0 = 0.055 ω1 = 1.0 ω2 = 1.0
	Teminal branch of Pma
	ma	2710.120			ω0 = 0.062 ω1 = 1.0 ω2 = 108.24	41-0.933, 110-0.908, 117-0.941, 210-0.911
	ma0	2717.793	15.347	<0.001	ω0 = 0.062 ω1 = 1.0 ω2 = 1.0
GSTO1	Teminal branch of Hgl
	ma	4450.655			ω0 = 0.065 ω1 = 1.0 ω2 = 18.7	11-0.988*, 21-0.873, 24-0.853, 195-0.974*, 213-0.936
	ma0	4454.959	8.608	0.003	ω0 = 0.061 ω1 = 1.0 ω2 = 1.0
	Teminal branch of Ttr
	ma	4453.983			ω0 = 0.082 ω1 = 1.0 ω2 = 999	47-0.991**,
	ma0	4458.928	9.890	0.002	ω0 = 0.082 ω1 = 1.0 ω2 = 1.0
GSTZ1	Teminal branch of Laf
	ma	3360.900			ω0 = 0.077 ω1 = 1.0 ω2 = 34.477	14-0.815, 181-0.819, 183-0.826
	ma0	3365.554	9.306	0.002	ω0 = 0.074 ω1 = 1.0 ω2 = 1.0
HPGDS	LCA of Cetartiodactyla
	ma	2891.856			ω0 = 0.105 ω1 = 1.0 ω2 = 163.254	183-0.980*,
	ma0	2896.024	8.335	0.004	ω0 = 0.106 ω1 = 1.0 ω2 = 1.0

^aBta: Bos taurus; Eca: Equus caballus; Hgl: Heterocephalus glaber; Has: Homo sapiens; Lwe: Leptonychotes weddellii; Laf: Loxodonta africana; Mmu: Mus musculus; Mlu: Myotis lucifugus; Nph: Neophocaena phocaenoides; Odi: Odobenus rosmarus divergens; Oor: Orcinus orca; Oar: Ovis aries; Pho: Pantholops hodgsonii; Pma: Physeter macrocephalus; Tla: Trichechus manatus latirostris; Ttr: Tursiops truncatus.

^blnL is the log-likelihood score.

^cCodons with posterior probabilities (pp) >80% in the BEB analyses. * pp >95%, ** pp >99%.