Table 3.

rpo A and rpoC mutations in MDR-TB isolates

Gene	Mutation site	Isolates n	Nucleotide substitution	Amino acid change	References
rpoC	812	1	A→G	D271G	Not reported
rpoC	994	1	G→A	G332S	19, 20
rpoC	1297	1	G→A	G433S	10, 12, 19, 20
rpoC	1300	1	C→G	P434V	21
rpoC	1301	1	C→T	P434V	21
rpoC	1301	1	C→A	P434Q	19, 20
rpoC	1354	3	T→C	F452L	21, 22
rpoC	1397	6	C→T	A466V	Not reported
rpoC	1448	3	T→C	V483A	11, 12, 19–22
rpoC	1448	9	T→G	V483G	10–12, 20, 21
rpoC	1471	3	A→G	I491V	10–12, 19, 20
rpoC	1519	3	T→G	L507V	12, 21
rpoC	1547	1	T→C	L516P	10, 19–21
rpoC	1562	1	C→A	A521D	10, 12, 20
rpoC	1573	1	C→A	H525N	10, 12
rpoA	344	1	G→C	G115A	Not reported
rpoA	379	1	A→G	T127A	Not reported
rpoA	559	1	A→G	T187A	10, 12, 20, 21
rpoA	569	1	A→G	D190G	20, 21

MDR-TB = multidrug-resistant tuberculosis.