Table 1.

Inhibition of the cell proliferation by niclosamide in colorectal cancer cell lines. Cells were treated with niclosamide for 72 hours and cell proliferation evaluated by MTS assay. IC₅₀ values were calculated using Graphpad Prism. APC and β-catenin mutation status were from literature reports (26, 27), wildtype (wt), mutation (mut), n.a (no report available).

Colon cancer Cell line	IC50 (μM)	Niclosamide inhibition	APC mutation	β-Catenin mutation
HCT116	0.31	Sensitive	wt	mut
CRC240	0.68	Sensitive	n.a	n.a
DLD-1	1.78	Sensitive	mut	wt
WIDR	870	Resistant	mut	n.a
COL0205	1655	Resistant	mut	wt
CRC57	2000	Resistant	n.a	n.a