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. Author manuscript; available in PMC: 2019 Jul 22.
Published in final edited form as: Sci Transl Med. 2018 Oct 24;10(464):eaat0150. doi: 10.1126/scitranslmed.aat0150

Fig. 1. Workflow of the systems biology–driven drug repositioning strategy.

Fig. 1.

The systematic drug repositioning strategy included two major components: (A) uncovering driver signaling networks by integrating multiple genomic profiles through a NPBSA algorithm and (B) an integrative analysis of DFNs and driver signaling networks for systematic drug repositioning. DNA-seq, DNA sequencing; KEGG, Kyoto Encyclopedia of Genes and Genomes; CNV, copy number variation; NCI-PID, NCI Pathway Interaction Database.