Table 3.

Comparison of published of RCTs on regional anaesthesia for breast surgery

Sr. no. (ref no.)	Authors	Journal, year	Sample size, groups (control, block)	Blinded?	Type of block	Intra-op analgesia measured?	Rescue analgesic	PCA?	PONV measured?	Conclusion
1 (9)	Bashandy et al	RegAnesth Pain Med, 2015	120; 60,60	No	Two injection, modified pecs block	Clinically (BP, HR)	Loading dose of Morphine 5 mg, when VAS >3	Morphine PCA given only when VAS >3	No	Pecs block provides excellent analgesia
2 (12)	Kulhari S et al	BJA.2016	40;20,20	No	TPVB, PecsII	No	none	Morphine PCA	No	Pecs II block provided superior analgesia
3 (3)	Syal K et al	Indian J Anaesth. 2017	65;22, 22,21	No	Two injection, modified pecs block	No	Fentanyl 1 mcg/Kg when VAS >4	No	No	TPVB > Pecs > LA infiltration
4 (14)	Kamiya H et al	EJA, 2018	60; 30,30	Yes	Pecs 2, two injection	BIS 40-50, Intra-op propofol requirement reduced but not Remifentanyl		No	No	Pecs block improved post-op pain
5 (13)	Matsumoto M	Sci Rep, 2018	49; 24,25	No	Pecs 1 + Serratus anterior plane block	Yes, criteria not mentioned	Not mentioned	Morphine PCA	yes	Pecs 1 + SAP block improved analgesia
6 (11)	Kim DH et al	Pain res manag, 2018	80; 40,40	No	Pecs-II, single injection	No	Fentanyl 0.4 mcg/kg in PACU, when VAS >4; Meperidine 25 or Tramadol 50 mg in ward	No	Side effects of analgesics measured as whole	Pecs II block reduced pain intensity and opioid requirement till 24 h
7 (10)	Kumar S et al	Indian J of Anaesth. 2018	50; 25, 25	No	Single injection, modified pecs block	Clinically, Fentanyl bolus 0.25 mcg/kg	I.v. Tramadol 2 mg/Kg when VAS >4	No	yes	Pecs block provides better post-op analgesia, reduced PONV
8 (16)	J Cross et al	RegAnesth Pain Med, 2018	128; 66,62	Yes	Pec 1 block	No	Intermittent morphine 3 mg bolus	No	No	Pecs 1 block does not improve peri-operative analgesia