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. 2018 Nov 30;84(6):934–939. doi: 10.1002/ana.25369

Figure 1.

Figure 1

Manhattan plot and regional association plots for the 3 novel risk loci identified in the current study. (A) Manhattan plot for any stroke in the transancestral meta‐analysis. The dotted line marks the threshold of genome‐wide significance. Novel loci are marked on the top. Note that NOS3 reached genome‐wide significance in the European‐only analysis. (B–D) Regional association plots for lead variants at the 3 novel loci: (B) NOS3, (C) COL4A1, and (D) DYRK1A. Shown is the region for the top signal ± 500 kb. The y‐axis represents the &minus;log(p value) from the European‐only fixed‐effects genome‐wide association study (GWAS) meta‐analysis (NOS3) or transancestral fixed‐effects GWAS meta‐analysis (COL4A1 and DYRK1A). Variants in linkage disequilibrium with the lead variant are shown in red (r 2 > 0.6), orange (r 2 > 0.4), yellow (r 2 > 0.2), and gray (r 2 < 0.2). OR = odds ratio; RAF = risk allele frequency.