Fig. 3. Non-obvious binding site similarities. On the left, the binding site alignment of the human enzyme arginine N-methyltransferase 6 (PDB-ID ; 4hc4 chain A, green) and N-4 cytosine-specific methyltransferase from Proteus vulgaris (PDB-ID ; 1boo chain A, orange) is presented with SAH in ball-and-stick representation. The corresponding binding site residues are colored according to the structure. The figure was generated with UCSF Chimera.64 The interaction patterns of SAH in the binding sites of the complexes with the PDB-IDs ; 4hc4 and ; 1boo are shown on the right (the schemes were generated with LigandScout 4.065).
