Fig. 7. Box plots of the DoGSite44-derived scaled hydrophobicity (solid filled boxes) and polarity (hatch pattern-filled boxes) scores of the binding sites of ligands that bind to multiple binding sites which do not show a high similarity using SiteHopper (PatchScore < 0.82, mainly hydrophobic). For comparison purposes, the box plot of these properties is also given for all ligands of the sc-PDB. “Super-promiscuous” ligands as defined by an earlier study are highlighted in gray.
