Table 2. SiteHopper similarity scores and the percentages of matched hydrophobic and aromatic interaction field grid points by IsoMIF for selected active site pairs.

Site 1 (PDB-ID, ligand-ID)	Site 2 (PDB-ID, ligand-ID)	SiteHopper scores			IsoMIF
		PatchScore	Shape-Tanimoto	Color-Tanimoto	Matched % hyd, % aro
1gs4, ZK5	3tc5, 3T5	0.56	0.24	0.10	62.5, 18.8
4j7u, YTZ	4iz0, 2BI	0.69	0.35	0.11	45.2, 35.5
1m8d, H4B	4a9e, 3PF	0.69	0.36	0.11	65.0, 10.0
3k6l, 2BB	2jih, 097	0.93	0.32	0.20	50.0, 0.0
4hkn, LU2	2nnl, ERD	0.87	0.33	0.10	56.8, 29.5
3lm5, QUE	2nnl, ERD	0.68	0.36	0.10	64.3, 0.0
4dgm, AGI	2nnl, ERD	0.75	0.33	0.14	73.0, 10.8
4dgm, AGI	4hmh, F94	0.75	0.38	0.12	63.6, 21.2
4hl5, 15W	1xo2, FSE	0.74	0.36	0.13	53.3, 16.7