Table 5. Effect of Various Solvents on the Knoevenagel Condensation Reaction at Room Temperaturea.
| entry | solvent | time | % conversionb | % selectivityb |
|---|---|---|---|---|
| 1 | toluene | 40 min | 99 | 100 |
| 2 | DMF | 15 min | 99 | 100 |
| 3 | MeOH | 30 min | 66 | 81 |
| 4 | acetonitrile | 15 min | 81 | 100 |
| 5 | DCM | 15 min | 99 | 100 |
| 6 | diethyl ether | 4 h | 61 | 100 |
Conditions: p-nitrobenzaldehyde (1 mmol), malononitrile (1 mmol), solvent (3 mL), catalyst (25 mg); catalyst: 10% KOH/HT.
Obtained from 1H NMR yield of the crude reaction mixture.