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. 2018 Jun 29;3(6):7086–7095. doi: 10.1021/acsomega.8b00767

Table 5. Effect of Various Solvents on the Knoevenagel Condensation Reaction at Room Temperaturea.

entry solvent time % conversionb % selectivityb
1 toluene 40 min 99 100
2 DMF 15 min 99 100
3 MeOH 30 min 66 81
4 acetonitrile 15 min 81 100
5 DCM 15 min 99 100
6 diethyl ether 4 h 61 100
a

Conditions: p-nitrobenzaldehyde (1 mmol), malononitrile (1 mmol), solvent (3 mL), catalyst (25 mg); catalyst: 10% KOH/HT.

b

Obtained from 1H NMR yield of the crude reaction mixture.