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. 2019 Jul 15;9:253. doi: 10.3389/fcimb.2019.00253

Figure 7.

Figure 7

SMVs induced the occurrence of pneumonia in mice in vivo. (A,B) Gross pathological changes (A) and histopathology (B) of pretreated with or without FOM. Tissues were stained with HE (10×). (C) Wright's-Giemsa stained smear of peritoneal fluid from infected mice. Neutrophil (white arrow) and Mϕ (black arrow) are presented (20×). (D) The total of WBC, neutrophil and Mϕ in the bronchoalveolar lavage (BAL) fluid of infected mice with FOM treatment were counted stained with Wright's-Giemsa. ψ p < 0.05, ψψ p < 0.01, ψψψ p < 0.001 compared with FOM treated group. (E,F) The level of IL-1β and IL-18 in the bronchoalveolar lavage (BAL) fluid of infected mice was detected by Elisa. (G) The levels of p-ERK, p-P38, and NLRP3 inflammasome protein in different SMVs-infected lungs. (H) Effects of FOM on MPO activity of SMVs-induced lung inflammation in mice. (I) Lung water content was calculated as the ratio of wet weight to dry weight, (J) vascular leakage in lung tissue was measured via injecting Evans blue dye. * p < 0.05, ** p < 0.01, *** p < 0.001 compared with the Control group. Data are means ± standard errors derived from three experiments.