Figure 11.

Schematic illustration of (A) synthetic procedure for MnOx-HMCNs, (B) incorporation of MnOx NPs into the framework of HMCNs, and (C) cellular uptake and dual pH-responsiveness of MnOx-HMCNs for T₁-weighted MRI and anti-cancer drug release. (D) (a) SEM image of RBCs-shaped HMCNs and (b) TEM images of MnOx-HMCNs with low magnification. (E) Plot of T₁^–1 versus Mn concentration of MnOx-HMCNs. (F) HIFU-triggered DOX release percentage under different irradiation parameters. Reprinted from ref (49) with permission from The Royal Society of Chemistry.