Table 3. Substrate Scope for 2-Mercaptobenzothiazoles.
entry | 2 (R) | 3 | yield (%)a | er |
---|---|---|---|---|
1 | 2a (H) | 3a | 99 | 89.5:10.5 |
2 | 2b (5-OMe) | 3b | 86 | 86:14 |
3 | 2c (5-OCF3) | 3c | 99 | 90.5:9.5 |
4 | 2d (5-Me) | 3d | 96 | 88.5:11.5 |
5 | 2e (6-Me) | 3e | 99 | 89.5:10.5 |
6 | 2f (5-Cl) | 3f | 61 | 90.5:9.5 |
7 | 2g (6-Cl) | 3g | 19 | 82.5:17.5 |
8 | 2h (5-F) | 3h | 92 | 89.5:10.5 |
9 | 2i (5-CN) | 3i | 51 | 87:13 |
10 | 2j (5-NO2) | 3j | 32 | 81:19 |
Isolated yield for 0.3 mmol scale reactions.