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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Prostate. 2019 Jan 20;79(6):628–639. doi: 10.1002/pros.23767

FIGURE 5.

FIGURE 5

Alternol suppresses xenograft tumor growth and reduces ATP production in malignant tissues. A, Subcutaneous xenografts were established with PC-3 cells in male nude mice and animals were treated with the solvent (as control, n = 10) or Alternol (10 mg/kg body weight, n = 10) by intraperitoneal injection three-time a week. Tumor size was measured at each treatment. Asterisks indicate significant difference compared to the control group (Student’s t-test, P < 0.05). B, Xenograft tumors and host liver tissues were harvested from animals at the end of experiments. Protein lysates were used for the ATPLite™ measurement as described earlier. The asterisk indicates a significant difference compared to the solvent control (Student’s t-test, P < 0.05). C-D, Xenograft tumors were fixed and paraffin-embeded for immunostaining with the antibodies as indicated. Semi-quantified data for the immnunosignals were summarized in panel D. The asterisk indicates a significant difference compared to the solvent control (Student’s t-test, P < 0.01)