Figure 4. Partial diagram of the “Signaling by SCF-KIT” pathway showing the feedback loop that generates the “p-STAT dimers” complex annotated in Reactome.

The entry point of the loop and “p-STAT dimers”, together with four reactions forming the loop, are highlighted in light blue. The reactions are labeled with names in the light-grey boxes. The target of drug sorafenib, KIT protein, is in the upstream of this loop and not shown here.